The Japan Statin Treatment Against Recurrent Stroke (J-STARS) Trial: Where to Now?
نویسنده
چکیده
Article history: Received 1 August 2015 Accepted 4 August 2015 Available online 6 August 2015 have been only 5 randomised controlled trials of statins in patients with prior stroke or TIA (total n = 9224) and the estimate of efficacy in preventing recurrent stroke is marginal (10.8% statin vs 12.1% control; odds ratio [OR]: 0.88, 95% CI: 0.77 to 1.00) (Manktelow and Potter, 2009). In the two trials that recorded the pathological subtype of stroke outcome events, allocation to statins (simvastatin 40 mg daily (Heart Protection Study Collaborative Group, 2004) or atorvastatin
منابع مشابه
The Current Status of Statins in Stroke Prevention
eNOS : endothelial Nitric Oxide Synthase; CARE: Cholesterol and Recurrent Events study; LIPID: Long-Term Intervention with Pravastatin in Ischemic Disease; JUPITER: Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin; s-CRP: sensitive C Reactive Protein; SPARCL: Stroke Prevention by Aggressive Reduction in Cholesterol Levels; J-STARS: Japan Statin T...
متن کاملRationale, design, and baseline features of a randomized controlled trial to assess the effects of statin for the secondary prevention of stroke: the Japan Statin Treatment Against Recurrent Stroke (J-STARS)
BACKGROUND Although statin therapy is beneficial for preventing first strokes, the benefit for recurrent stroke and its sub-types remains unknown in Asian populations. The aim of this study is to examine the role of pravastatin in the secondary prevention of stroke in Japanese patients. METHODS This is a multicenter, randomized, open-label, parallel group study of patients with noncardioembol...
متن کاملThe Japan Statin Treatment Against Recurrent Stroke (J-STARS): A Multicenter, Randomized, Open-label, Parallel-group Study
BACKGROUND Although statin therapy is beneficial for the prevention of initial stroke, the benefit for recurrent stroke and its subtypes remains to be determined in Asian, in whom stroke profiles are different from Caucasian. This study examined whether treatment with low-dose pravastatin prevents stroke recurrence in ischemic stroke patients. METHODS This is a multicenter, randomized, open-l...
متن کاملLong-Term Effect of Pravastatin on Carotid Intima–Media Complex Thickness
BACKGROUND AND PURPOSE The effect of statins on progression of carotid intima-media complex thickness (IMT) has been shown exclusively in nonstroke Western patients. This study aimed to determine the effect of low-dose pravastatin on carotid IMT in Japanese patients with noncardioembolic ischemic stroke. METHODS This is a substudy of the J-STARS trial (Japan Statin Treatment Against Recurrent...
متن کاملAggressive statin treatment, very low serum cholesterol levels and haemorrhagic stroke: is there an association?
PURPOSE OF REVIEW To assess the potential association between haemorrhagic stroke and achieving very low serum cholesterol levels with aggressive statin treatment. RECENT FINDINGS The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study showed a reduction in both fatal and nonfatal stroke but an increase in the risk for haemorrhagic stroke during high-dose atorvastat...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2015